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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4
All Species:
20.61
Human Site:
T142
Identified Species:
30.22
UniProt:
O43172
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43172
NP_004688.2
522
58449
T142
N
I
L
S
V
V
G
T
D
A
L
K
K
T
K
Chimpanzee
Pan troglodytes
XP_520198
559
62217
T179
N
I
L
S
V
V
G
T
D
A
L
K
K
T
K
Rhesus Macaque
Macaca mulatta
XP_001102859
521
58408
T141
N
I
L
S
V
V
G
T
D
A
L
K
K
T
K
Dog
Lupus familis
XP_532038
521
58332
T141
N
I
L
S
V
V
G
T
D
A
L
K
K
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAW6
521
58352
T141
N
I
L
S
V
V
G
T
D
A
L
K
K
T
K
Rat
Rattus norvegicus
Q5BK30
415
45841
V45
S
T
D
V
N
T
L
V
G
E
I
Q
K
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518220
390
43930
D20
L
K
K
T
K
K
D
D
E
R
S
K
K
S
R
Chicken
Gallus gallus
Q5ZMA2
505
55116
E129
K
E
V
T
A
A
R
E
A
L
A
T
L
K
P
Frog
Xenopus laevis
Q5FWQ6
415
45899
V45
T
T
D
V
D
L
V
V
G
E
I
Q
K
A
E
Zebra Danio
Brachydanio rerio
Q1LV15
415
45916
V45
E
T
D
V
E
E
L
V
L
E
I
R
A
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
S40
F
R
K
E
A
D
L
S
T
E
V
E
K
K
F
Honey Bee
Apis mellifera
XP_393186
525
59172
D135
L
L
A
N
L
G
E
D
A
I
K
K
K
H
E
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
S122
C
R
V
I
S
R
L
S
K
E
L
T
A
A
R
Sea Urchin
Strong. purpuratus
XP_795434
502
56264
A127
M
A
D
Q
D
K
Q
A
K
K
A
N
K
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22212
554
61823
N161
L
L
T
R
Y
D
I
N
G
Q
L
D
K
L
V
Baker's Yeast
Sacchar. cerevisiae
P20053
465
52424
N95
E
N
I
N
N
M
E
N
I
N
G
E
E
V
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99
99.2
N.A.
98.8
25.4
N.A.
71.2
21
24.1
24.3
N.A.
22.2
58.2
22
62
Protein Similarity:
100
93.1
99.2
99.6
N.A.
99.4
40.6
N.A.
73.3
41.3
41.3
41.5
N.A.
39.6
72.9
40.6
77
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
13.3
0
6.6
0
N.A.
6.6
13.3
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
40
13.3
33.3
20
N.A.
26.6
40
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
31.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.7
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
13
7
0
7
13
32
13
0
13
19
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
25
0
13
13
7
13
32
0
0
7
0
0
7
% D
% Glu:
13
7
0
7
7
7
13
7
7
32
0
13
7
7
25
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
0
7
32
0
19
0
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
32
7
7
0
0
7
0
7
7
19
0
0
0
0
% I
% Lys:
7
7
13
0
7
13
0
0
13
7
7
44
75
13
38
% K
% Leu:
19
13
32
0
7
7
25
0
7
7
44
0
7
7
0
% L
% Met:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
32
7
0
13
13
0
0
13
0
7
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
0
7
0
0
7
0
0
7
0
13
0
0
0
% Q
% Arg:
0
13
0
7
0
7
7
0
0
7
0
7
0
0
13
% R
% Ser:
7
0
0
32
7
0
0
13
0
0
7
0
0
7
0
% S
% Thr:
7
19
7
13
0
7
0
32
7
0
0
13
0
32
0
% T
% Val:
0
0
13
19
32
32
7
19
0
0
7
0
0
13
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _